Subdural motor cortex stimulation in Parkinson's disease does not modify movement‐related rCBF pattern
Identifieur interne : 002527 ( Main/Exploration ); précédent : 002526; suivant : 002528Subdural motor cortex stimulation in Parkinson's disease does not modify movement‐related rCBF pattern
Auteurs : Antonio P. Strafella [Canada] ; Andres M. Lozano [Canada] ; Anthony E. Lang [Canada] ; Ji Hyun Ko [Canada] ; Yu-Yan Poon [Canada] ; Elena Moro [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-10-31.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Cerebrovascular Circulation (physiology), Deep Brain Stimulation (methods), Dose-Response Relationship, Radiation, Emission tomography, Female, Functional imaging, Humans, Male, Motor Cortex (blood supply), Motor cortex, Movement (physiology), Nervous system diseases, PET, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Positron, Positron emission tomography, Positron-Emission Tomography (methods), Subdural, functional imaging, motor cortex stimulation.
- MESH :
- blood supply : Motor Cortex.
- methods : Deep Brain Stimulation, Positron-Emission Tomography.
- pathology : Parkinson Disease.
- physiology : Cerebrovascular Circulation, Movement.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Analysis of Variance, Dose-Response Relationship, Radiation, Female, Humans, Male.
Abstract
There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [15O] H2O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF‐condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement‐related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement‐related activation pattern in patients with advanced PD. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21691
Affiliations:
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This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [15O] H2O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF‐condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement‐related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement‐related activation pattern in patients with advanced PD. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li><li>Québec</li></region><settlement><li>Montréal</li><li>Toronto</li></settlement><orgName><li>Université McGill</li><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></region><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Poon, Yu An" sort="Poon, Yu An" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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